Desenvolvimento, estudo de estabilidade e avaliação da atividade antifúngica da saliva artificial com extrato de aloe vera

Abstract

During radiotherapy and chemotherapy of head and neck cancer, salivary glands are among the healthy tissues that can be affected in the process, resulting in permanent changes in the quality and quantity of saliva applied, as well as the appearance of xerostomia-induced mucositis and candidiasis. The objective of this work was to develop a modification of artificial saliva with Aloe vera extract, to perform the Accelerated Stability Study and to evaluate the antifungal activity of the Candida albicans front. It was prepared based on artificial saliva and incorporated or extracted from Aloe vera na 50% concentration. For the culture medium used, Aggar Sabouraud Dextrose for yeast selection, sterile disc diffusion method. No stability test because the formulations were stored at different temperatures: 5 ± 2 ° C, 24 ± 2 ° C and 40 ± 2 ° C. A pH test was performed on days 0,1,7,15,30, 60 and 90. Stability tests were observed, remaining stable during the study and pH ranged from 5.49 to 5.66 No antifungal activity test, no inhibition halo for Candida Albicans. antifungal activity was performed, further research, formulations and use of different solvents for Aloe vera extraction is required, as other studies in the study period when Aloe vera was used to inhibit Candida albicans.